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Wernicke–Korsakoff syndrome
Wernicke–Korsakoff syndrome (WKS), also called wet brain, Korsakoff's psychosis, and alcoholic encephalopathy,〔 is the combined presence of Wernicke's encephalopathy (WE) and Korsakoff's syndrome. Due to the close relationship between these two disorders, people with both are usually diagnosed with WKS, as a single syndrome. It is a manifestation of thiamine (vitamin B1) deficiency, a spectrum of disorders which also encompasses beriberi, Wernicke's encephalopathy, and Korsakoff's psychosis. These disorders may manifest concurrently or separately. WKS is usually secondary to alcohol abuse. It mainly causes vision changes, ataxia and impaired memory.〔
Wernicke's encephalopathy and WKS is most commonly seen in people who are alcoholic, and only 20% of cases are identified before death. This failure in diagnosis of WE and thus treatment of the disease leads to death in approximately 20% of cases, while 75% are left with permanent brain damage associated with WKS. Of those affected, 25% require long-term institutionalization in order to receive effective care.〔
==Signs and symptoms==
The syndrome is a combined manifestation of two namesake disorders, Wernicke's encephalopathy and Korsakoff's psychosis, named after Carl Wernicke and Sergei Korsakoff respectively. It involves an acute Wernicke-encephalopathy phase, followed by the development of a chronic Korsakoff's syndrome phase.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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